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This cohort study provided evidence supporting the association of tirzepatide treatment, compared to GLP-1 receptor agonists, with lower hazards of all-cause mortality and adverse CV or kidney events through a head-to-head comparison in patients with type 2 diabetes, Vin-Cent Wu, MD, PhD, attending physician in the department of internal medicine at National Taiwan University Hospital, and colleagues wrote These insights advocate for the integration of tirzepatide into therapeutic strategies for managing type 2 diabetes and highlight its potential to enhance current clinical practice. Wu and colleagues analyzed data from the TriNetX U.S

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While it enhances the transcription of glucose transport genes (such as GLUT1 and GLUT3) and key rate-limiting enzymes in glycolysis (such as PKM2 and HK2)

[DOI] [PubMed] [Google Scholar] 10.Agarwal A., Sengupta P., Durairajanayagam D